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xii | |
| Dedications |
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xxvi | |
| Scientists Honored for Pioneering Research |
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xxix | |
| Preface |
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xxxv | |
| Acknowledgments |
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xxxvi | |
| I. EPIDEMIOLOGY AND RISK FACTORS |
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1 | (30) |
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The Transition from Normal Functioning to Dementia in the Aging Population |
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3 | (8) |
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Epidemiology of Alzheimer's Disease and Dementia: Advances and Challenges |
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11 | (12) |
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Epidemiology of Dementia in Down's Syndrome |
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23 | (8) |
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| II. GENETICS |
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31 | (66) |
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A Genomic Search for Alzheimer's Disease Genes |
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33 | (1) |
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Margaret A. Pericak-Vance |
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Candidate Genes Showing No Evidence of Association with Alzheimer's Disease: Results of the NIMH-AD Genetics Initiative |
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33 | (20) |
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Laura A. MacKenzie-Ingano |
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Familial Alzheimer's Disease with Spastic Paraparesis Associated with a Mutation at Codon 261 of the Presenilin 1 Gene |
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53 | (8) |
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Genetic Analysis of the Presenilin Pathway in Drosophila |
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61 | (10) |
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Molecular Genetics and Transgenic Modeling of the Tauopathies |
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71 | (16) |
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Regulation of Four-repeat tau Expression: Interactions between Exon and Intron Splicing Regulatory Sequences |
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87 | (10) |
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| III. DIAGNOSIS AND CLINICAL COURSE |
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97 | (232) |
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Preclinical Prediction of AD: Relation Between Neuropsychological and Neuroimaging Findings |
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99 | (12) |
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Neuropsychological Detection of Preclinical Alzheimer's Disease: Results of a Neuropathological Series of `Normal' Controls |
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111 | (12) |
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Potentially Reversible Conditions in Memory Clinic Patients |
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123 | (6) |
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The Alzheimer's Disease Centers' Neuropsychological Database Initiative: A Resource for Alzheimer's Disease Prevention Trials |
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129 | (12) |
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Mild Cognitive Impairment: Transition from Aging to Alzheimer's Disease |
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141 | (12) |
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Brain Functional Imaging in Early and Preclinical Alzheimer's Disease |
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153 | (12) |
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Amyloid, PHF-tau, Ubiquitin and Synaptic Markers in the Progression of Alzheimer's Disease: Immunochemical Analyses of Frontal Cortex from Prospectively Studied Elderly Humans |
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165 | (16) |
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Imaging the Consequences of Alzheimer's Disease Pathology |
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181 | (12) |
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Influence of apoE Genotype and PET Brain Imaging on Preclinical Prediction of Alzheimer's Disease |
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193 | (12) |
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Margaret A. Pericak-Vance |
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Overview of Vascular Dementia |
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205 | (14) |
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Clinical and Imaging Characteristics of Vascular Dementia in a Memory Clinic |
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219 | (10) |
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MRI of Entorhinal Cortex and Hippocampus in Alzheimer's Disease, Subcortical Ischemic Vascular Dementia and Mixed Dementia |
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229 | (8) |
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Olfactory Function and Event-related Potentials in Alzheimer's Disease |
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237 | (16) |
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Phenotypic Differences in Cholinergic Markers within the Nucleus Basalis in Individuals with Mild Cognitive Impairment |
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253 | (12) |
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Evaluating CNS Biomarkers for Alzheimer's Disease |
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265 | (10) |
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CSF Markers for Early Alzheimer's Disease |
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275 | (10) |
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CSF-Phospho-tau (181P) as a Promising Marker for Discriminating Alzheimer's Disease from Dementia with Lewy Bodies |
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285 | (8) |
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Increased Levels of a Minor Glycoform of Acetylcholinesterase in Alzheimer's Disease Brain and Cerebrospinal Fluid |
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293 | (10) |
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Plasma β-Amyloid as a Surrogate Genetic Marker in Late-onset Alzheimer's Disease |
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303 | (8) |
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Levels of Total and Deposited Aβ are Correlated with Dementia |
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311 | (8) |
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What Should We Tell Patients Attending a Memory Disorders Clinic About Their Diagnosis? |
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319 | (10) |
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| IV. MECHANISMS OF NEURODEGENERATION |
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329 | (12) |
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Innate Immunity, Autotoxicity and Degenerative Neurologies |
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331 | (10) |
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Neuroinflammatory Responses in the Alzheimer's Disease Brain Promote the Oxidative Post-translational Modification of Amyloid Deposits |
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341 | (22) |
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Plasma Antioxidants and Oxidative DNA Damage in Lymphocytes from Normal Aged People and Alzheimer's Disease Patients |
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363 | (8) |
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Oxidative Damage and Antioxidant Responses in Alzheimer's Disease |
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371 | (8) |
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Cyclooxygenase (COX)-2 and Clinical Progression of Alzheimer's Disease Dementia: Implications in the Role of Neuronal COX-2 in Cell Cycle |
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379 | (14) |
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Parallels between the Redox Properties and Toxicity of Aβ in Alzheimer's Disease and Mutant Cu/Zn-SOD in Familial Amyotrophic Lateral Sclerosis |
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393 | (14) |
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Β-Amyloid Toxicity: Diverse Biological Activities Drive Multiple Cellular Mechanisms |
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407 | (14) |
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Mechanisms of Aβ Production and Aβ Degradation: Routes to the Treatment of Alzheimer's Disease |
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421 | (12) |
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A High Fat, High Cholesterol Diet Accelerates β-Amyloid Accumulation in the CNS of a Transgenic Mouse Model of Alzheimer's Disease |
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433 | (16) |
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Electron Microscopy and X-ray Diffraction Studies further Confirm the Efficacy of PTI-00703TM® (Cat's Claw Derivative) as a Potential Inhibitor of Alzheimer's β-Amyloid Protein Fibrillogenesis |
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449 | (12) |
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Accelerated Aβ Generation in a Cell Model of Alzheimer's Disease-related Endosomal-Lysosomal System Upregulation |
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461 | (8) |
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The Amyloid Precursor Protein V717I Mutation Increases Susceptibility to Cell Death in a Cholesterol-dependent Manner |
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469 | (10) |
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Laura A. MacKenzie Ingano |
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Intracellular and Secreted Aβ42/40 Ratios Are Differently Influenced by APP Mutations |
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479 | (8) |
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Familial British Dementia |
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487 | (8) |
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Cellular Metabolism of Familial British Dementia-associated BRI-L |
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495 | (12) |
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A Decamer Duplication in the BRI Gene Originates a de novo Amyloid Peptide that Causes Dementia in a Danish Kindred |
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507 | (8) |
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Familial Alzheimer's Disease-linked Mutant Presenilins Attenuate Capacitative Calcium Entry |
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515 | (6) |
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Presenilin-1 Is a Regulatory Component of the Cadherin Cell Adhesion Complex: Implications for Alzheimer's Disease |
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521 | (10) |
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Presenilins and Notch Signaling Pathway |
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531 | (10) |
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Functional Consequences of the Association of PS1 with β-Catenin |
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541 | (8) |
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A Novel Protease Active Site Motif Conserved in Presenilins and Polytopic Bacterial Aspartyl Proteases? |
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549 | (10) |
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The Unfolded Protein Response-mediated Upregulation of BiP and CHOP Is not Affected by Presenilin Expression |
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559 | (10) |
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Mechanisms of α-Synuclein and NAC Fibrillogenesis |
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569 | (18) |
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Neurofibrillary Degeneration: Patterns of Tau Isoform Expression |
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587 | (14) |
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Phosphorylation, Microtubule Binding and Aggregation of Tau Protein in Alzheimer's Disease |
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601 | (8) |
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Phosphorylation of Protein Tau and Rescue of Protein Tau-induced Axonopathy by GSK-3β in GSK-3βxhtau40 Double Transgenic Mice |
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609 | (12) |
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Pathogenic Implication of Altered Tau Properties Caused by FTDP-17 Mutations |
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621 | (10) |
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A Hexapeptide Motif (306VQIVYK311)-forming β Structure Induces the Aggregation of Tau Protein to Paired Helical Filaments |
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631 | |
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| V. ANIMAL AND CELLULAR MODELS |
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341 | (364) |
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Formation of Neurofibrillary Tangles in Mouse Brain |
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643 | (8) |
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Inducible Transgenic Expression of Wild-type tau in H4 Neuroglioma Cells |
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651 | (10) |
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Lewy-like Pathology in Mice Transgenic for Mutant (A53T) and Wild-type Human α-Synuclein |
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661 | (10) |
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Somal and Neuritic Accumulation of the Parkinson's Disease-associated Mutant [A30P]α-Synuclein in Transgenic Mice |
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671 | (8) |
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Ex vivo Transmission of Mouse-adapted Prion Strains to N2a and GT1-7 Cell Lines |
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679 | (8) |
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In Vivo Perturbation of Lysosomal Function Promotes Neurodegeneration in the PS1M146V/APPK670N,M671L Mouse Model of Alzheimer's Disease Pathology |
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687 | (10) |
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Changes in Cognitive Characteristics of Tg(APP)CRND8 Mice at Early Stages of Immunization with Beta-Amyloid Peptide |
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697 | (8) |
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| VI. THERAPEUTICS AND THERAPEUTIC STRATEGIES |
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705 | (116) |
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Galantamine, a Novel Treatment for Alzheimer's Disease: A Review of Long-term Benefits to Patients and Caregivers |
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707 | (18) |
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Benefits of Donepezil on Cognition, Function and Neuropsychiatric Symptoms in Patients with Mild and Moderate Alzheimer's Disease over One Year |
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725 | (14) |
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Characterization of Alzheimer's β-Secretase Protein BACE: Processing and Other Post-translational Modifications |
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739 | (1) |
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Androgen Treatment Reduces Cognitive Deficits in Female apoE4 Transgenic Mice |
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739 | (8) |
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Studies with the Memory-enhancing Drug AIT-082 in PC12 Cells |
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747 | (12) |
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Generation of Auto-antibodies toward Alzheimer's Disease Vaccination |
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759 | (18) |
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Toward the Identification of γ-Secretase: Using Transition State Analog Inhibitors |
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777 | (12) |
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Photoactivated, Active-site-directed γ-Secretase Inhibitors Covalently Label Presenilin 1 |
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789 | (10) |
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Functional Analysis of β-Secretase Using Mutagenesis and Structural Homology Modeling |
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799 | (10) |
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Therapeutic Approaches to Prion Diseases: In Vitro Studies with Tetracycline Compounds |
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809 | (12) |
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| VII. PSYCHOSOCIAL CARE |
|
821 | (14) |
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Influence of a Memory Training Program on Attention and Memory Performance of Patients with Dementia |
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823 | (10) |
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Prediction of Use of Emergency Community Services by Cognitively Impaired Seniors who Live Alone: Preliminary Findings of a Prospective Study |
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833 | (2) |
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| Index |
|
835 | |
Other versions by this Author
eCampus.com Device Compatibility Matrix
Apple iOS | iPad, iPhone, iPod
Android Devices | Android Tables & Phones OS 2.2 or higher | *Kindle Fire
Windows 10 / 8 / 7 / Vista / XP
Mac OS X | **iMac / MacbookEnjoy offline reading with these devices
Android 2.2 +
