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Natural Products and Drug Research |
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1 | (78) |
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Structural diversity of surface lipids from spiders |
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1 | (7) |
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Chemistry of marine pyrrole-imidazole alkaloids |
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8 | (10) |
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Synthesis of non-cyclized pyrrole-imidazole alkaloids |
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9 | (4) |
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Synthesis of the cyclized oroidin skeleton |
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13 | (5) |
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Natural products and their role in pesticide discovery |
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18 | (10) |
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Cripowellin--microderivatization |
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18 | (2) |
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Rocaglamide -- synthesis towards new analogs |
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20 | (2) |
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Pyrenocine -- total synthesis of analogs |
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22 | (2) |
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PF 1022A -- synthesis of an aza analog of the cyclodepsipeptide |
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24 | (4) |
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Common principles in marginolactone (macrolactone) biosynthesis |
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28 | (10) |
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Biosynthetic building blocks |
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28 | (3) |
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Biosynthetic relationships |
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31 | (2) |
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33 | (3) |
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Manipulation of the metabolite pattern |
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36 | (2) |
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Synthesis and biological activity of leukotriene derivatives |
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38 | (5) |
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Diazoketones - versatile starting materials for the diastereoselective synthesis of β-lactams |
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43 | (5) |
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43 | (3) |
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Mechanistic Considerations |
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46 | (2) |
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Selenium compounds in chemical and biochemical oxidation reactions |
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48 | (5) |
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Synthetic routes to oligo-tetrahydrofurans and oligo-pyrrolidines |
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53 | (7) |
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Glycosphingolipids of myelin: Potential target antigens of demyelinating antibody activity in multiple sclerosis |
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60 | (6) |
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Binding of human mAbs to surface antigens of cultured brain cells |
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61 | (1) |
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Reaction pattern of autoantibody DS1F8 with intracellular antigens |
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62 | (1) |
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Reaction pattern of mAb DS1F8 with purified lipids in ELISA |
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62 | (1) |
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63 | (3) |
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Combinatorial chemistry for the identification of novel bioactive compounds |
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66 | (6) |
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Combinatorial chemistry in drug discovery |
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66 | (1) |
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Molecular diversity on rigid scaffolds |
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67 | (1) |
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Solid-phase synthesis toward multiple core structures |
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68 | (4) |
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Supramolecular polymer chemistry based on multiple hydrogen bonding |
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72 | (7) |
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Enzymatic Synthesis and Biotransformation |
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79 | (54) |
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Enzymatic C--C coupling: The development of aromatic prenylation for organic synthesis |
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79 | (10) |
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80 | (2) |
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Production, stability and substrate specificity of `ubiA-prenyltransferase' |
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82 | (2) |
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Parametrization and scale-up |
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84 | (2) |
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86 | (3) |
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Are there enzyme-catalyzed Diels--Alder reactions? An investigation into the polyketide-synthase system required for the biosynthesis of cytochalasans |
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89 | (6) |
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Screening of blocked mutants of Zygosporium masonii |
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89 | (1) |
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Synthesis of derivatives of putative early polyketide intermediates and incorporation experiments |
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90 | (2) |
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Towards the characterization of the PKS gene cluster associated with cytochalasin D biosynthesis in Z. masonii |
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92 | (3) |
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The truth about enzymatic halogenation in bacteria |
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95 | (7) |
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95 | (3) |
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Haloperoxidases and halometabolite biosynthesis |
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98 | (1) |
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The search for new, specific halogenases |
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98 | (4) |
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Enzymatic Baeyer--Villiger oxidation with cyclohexanone monooxygenase: A new system of cofactor regeneration |
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102 | (9) |
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Cyclohexanone monooxygenase |
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103 | (1) |
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A new method of NADPH regeneration |
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103 | (2) |
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Baeyer--Villiger oxidation with the system cyclohexanone monooxygenase/formate dehydrogenase |
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105 | (1) |
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Optimization of the reaction conditions |
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105 | (1) |
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Application of the new coupled enzyme system |
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106 | (5) |
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The synthesis of optically active [2.2]paracyclophanes by biotransformations |
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111 | (10) |
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Preparation of optically active planar chiral paracyclophanes |
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111 | (1) |
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Biocatalysis in the enantioselective preparation of cyclophanes |
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111 | (2) |
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Biotransformation of monosubstituted [2.2]paracyclophanes |
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113 | (1) |
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Bioreduction of 4-formyl[2.2]paracyclophane 1 |
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113 | (1) |
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Synthesis of 4-hydroxy[2.2]paracyclophane 3 using hydrolases |
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114 | (3) |
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Synthesis of optically active disubstituted [2.2]paracyclophanes |
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117 | (1) |
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Screening for bioreduction and hydrolytic activity |
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118 | (1) |
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Chemoenzymatic synthesis of 5-formyl-4-hydroxy[2.2]paracyclophane (6) |
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119 | (2) |
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Multivariate analysis of biotransformations for a more effective strain selection (Intelligent screening) |
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121 | (6) |
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123 | (1) |
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123 | (1) |
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Hydration of trans-nerolidol |
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124 | (1) |
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Epoxidation of trans-nerolidol |
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124 | (1) |
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Hydroxylation of aristolenepoxide |
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125 | (1) |
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125 | (2) |
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Extending the applicability of lipases and esterases for organic synthesis |
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127 | (6) |
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127 | (1) |
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Resolution of a Bryostatin 1 building block |
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127 | (1) |
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Directed evolution of an esterase |
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128 | (5) |
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Carbohydrate Chemistry and Glycobiology |
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133 | (52) |
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Multivalent neoglycoconjugates for the inhibition of mannose-sensitive carbohydrate-protein interactions |
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133 | (18) |
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Multivalency in carbohydrate-protein interactions |
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133 | (1) |
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Synthesis of multivalent neoglycoconjugates |
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134 | (1) |
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Chemistries for glycocluster synthesis |
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134 | (1) |
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Core molecules for glycocluster and glycodendrimer synthesis |
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135 | (5) |
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Synthesis of mannose-containing glycoclusters and glycodendrimers |
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140 | (3) |
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Testing of the antiadhesive properties of synthetic α-mannosyl clusters |
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143 | (6) |
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149 | (2) |
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Octyl O- and S-glycosides related to the GPI anchor of Trypanosoma brucei as probes for in vitro galactosylation by trypanosomal α-galactosyltransferases |
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151 | (9) |
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152 | (1) |
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152 | (2) |
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Enzymatic α-galactosylation |
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154 | (3) |
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Preparation of trypanosome membrane fractions |
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157 | (3) |
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Convenient synthesis of C-branched carbohydrates from glycals |
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160 | (6) |
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Manganese(III) acetate-mediated additions |
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160 | (1) |
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Ceric(IV) ammonium nitrate (CAN)-mediated additions |
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161 | (1) |
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Mechanistic considerations |
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161 | (2) |
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Addition of malonates in the presence of nucleophiles |
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163 | (1) |
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164 | (2) |
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Enzymatic tools for the synthesis of nucleotide (deoxy)sugars |
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166 | (6) |
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Enzymatic synthesis of nucleotide (deoxy)sugars from sucrose |
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166 | (1) |
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In situ regeneration of UDP-D-galactose from sucrose |
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167 | (2) |
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Enzymatic synthesis of GDP-D-mannose from d-mannose |
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169 | (3) |
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The enzyme dTDP-glucose-4, 6-dehydratase as a tool for the synthesis of deoxy sugars |
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172 | (13) |
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174 | (7) |
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Synthesis of dTDP-ascarylose |
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181 | (2) |
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183 | (2) |
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Peptide Chemistry and Applications |
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185 | (48) |
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α,α-Disubstituted amino acids and bicyclic lactams: Potential building blocks for the synthesis of peptide mimics |
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185 | (8) |
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Synthesis of enantiomerically pure β-ketoesters and derivatives via enzyme-catalyzed kinetic resolutions |
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186 | (1) |
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Synthesis of α,α-disubstituted amino acids |
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187 | (1) |
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Synthesis of bicyclic turn mimetics |
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188 | (1) |
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Synthesis of bicyclic lactams |
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188 | (1) |
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Synthesis of bridged tetrapeptides |
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189 | (4) |
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β-Amino acids as building blocks for peptide modification |
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193 | (8) |
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β-Amino acids in medicinal chemistry - a brief survey |
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193 | (1) |
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Do β-amino acids induce secondary structure elements? |
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194 | (1) |
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Synthesis of enantiomerically pure β-amino acids |
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195 | (2) |
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Cyclic RGD peptides containing β-amino acids |
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197 | (4) |
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Reactions of chelated amino acid ester enolates and their application to natural product synthesis |
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201 | (6) |
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Asymmetric aldol reactions |
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202 | (1) |
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Asymmetric chelate Claisen rearrangements |
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203 | (1) |
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Chelate Claisen rearrangements of chiral esters |
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203 | (1) |
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Chelate Claisen rearrangements in the presence of chiral ligands |
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204 | (3) |
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Cyclodepsipeptides: From natural product to anthelmin-tically active synthetic enniatins |
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207 | (8) |
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Total synthesis of enniatins |
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207 | (1) |
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Optimization strategy of enniatins |
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208 | (4) |
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NMR spectroscopic investigations of enniatins |
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212 | (1) |
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Synthesis of a tritium labeled enniatin |
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212 | (1) |
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Enzymatic biosynthesis of (R)-lactic acid containing enniatins |
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213 | (1) |
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213 | (2) |
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Artificial biomimetic receptor molecules |
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215 | (10) |
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Synthetic adrenaline receptors |
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215 | (1) |
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Recognition of amino alcohols |
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215 | (2) |
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Recognition of the catechole |
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217 | (2) |
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Biomimetic and chiral recognition of adrenaline |
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219 | (1) |
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Conclusions and perspectives |
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220 | (1) |
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Synthetic peptide receptors |
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221 | (1) |
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Intermolecular β-sheet stabilization |
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221 | (2) |
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Conclusions and perspectives |
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223 | (2) |
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Design and synthesis of modulators of sphingolipid biosynthesis |
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225 | (8) |
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The need for synthetic modulators of sphingolipid biosynthesis |
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225 | (2) |
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227 | (1) |
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227 | (1) |
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227 | (3) |
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230 | (3) |
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Nucleic Acid Chemistry: Mechanisms and Mimetics |
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233 | (58) |
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Structural alterations of the isopolar phosphonate bond in nucleotide and oligonucleotide analogs |
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233 | (9) |
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5-(Adenin-9-yl)pentofuranosylphosphonates and 2-(adenin-9-yl)cycloalkyloxymethanephosphonates |
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233 | (2) |
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O-Phosphonomethylnucleosides |
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235 | (1) |
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O-Phosphonoalkylidenenucleosides |
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236 | (1) |
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5'-C and 3'-C-phosphorylnucleosides |
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237 | (1) |
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5'-Deoxy-4'-phoshonomethoxynucleosides |
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237 | (1) |
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O-Phosphonomethyl group in oligonucleotides |
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238 | (2) |
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240 | (2) |
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DNA Repair: From model compounds to artificial enzymes |
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242 | (13) |
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The degradation and repair of the genetic information |
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242 | (1) |
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DNA Photolyase Repair Enzymes |
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242 | (3) |
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Mechanistic investigations with model compounds |
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245 | (1) |
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General aspects and cleavage assay |
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245 | (2) |
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pH-Dependency of the cleavage reaction |
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247 | (1) |
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Solvent dependency of the cleavage reaction |
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248 | (1) |
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The role of the second cofactor |
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249 | (1) |
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Bis-deazaflavin model systems |
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249 | (1) |
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Mixed flavin and deazaflavin model systems |
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250 | (1) |
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251 | (1) |
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The third generation model compounds |
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251 | (1) |
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Towards artificial DNA photolyases |
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252 | (3) |
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Alanyl-PNA: A model system for DNA using a linear peptide backbone as scaffold |
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255 | (7) |
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Alanyl pepeptide nucleic acid (PNA): constitution and model for duplex formation |
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255 | (1) |
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Pairing properties of analyl-PNA |
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256 | (2) |
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Analyl-PNA: A DNA i-motif analog |
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258 | (1) |
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Intercalation to alanyl-PNA |
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259 | (1) |
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Amino acid side chain-nucleobase interactions |
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260 | (2) |
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New PNA buildings block for antisense research |
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262 | (10) |
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263 | (2) |
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Properties of the new homo-oligomers |
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265 | (1) |
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Synthesis and properties of hetero-oligomers |
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266 | (3) |
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269 | (3) |
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RNAse active site model systems |
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272 | (9) |
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Studies on hairpin ribozymes |
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281 | (10) |
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Design of the HpH5 ribozyme and its substrate |
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283 | (1) |
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284 | (1) |
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Synthesis of substrate RNAs |
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285 | (1) |
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Quantitative assay of ribozyme activity |
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286 | (1) |
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Kinetic analysis of HpH5 ribozyme cleavage |
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287 | (4) |
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Biosynthetic Pathways and Biochemistry |
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291 | (67) |
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Neuropeptide Y: A molecule for hunger, stress and memory |
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291 | (7) |
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Annette G. Beck-Sickinger |
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291 | (1) |
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What are the molecular targets of neuropeptide Y? |
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292 | (1) |
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What can we learn from structure-activity studies? |
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293 | (1) |
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Analogues of neuropeptide Y: Which amino acids are essential? |
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294 | (1) |
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Segments of the peptide - how do we get them active as well? |
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294 | (1) |
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Centrally truncated peptides: NPY analogs that miss the middle segment |
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295 | (1) |
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Why do we work with neuropeptide Y? |
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296 | (2) |
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Biosynthetic studies on deoxysugars: Implications for enzyme-mediated synthesis of deoxyoligosaccharides |
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298 | (7) |
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298 | (1) |
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Synthesis of deuterated deoxysugars |
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299 | (2) |
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301 | (1) |
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302 | (3) |
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Investigations on the biosynthesis of landomycin A |
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305 | (8) |
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Landomycins - an introduction |
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305 | (1) |
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Biosynthetic studies on the aglycone moiety |
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305 | (2) |
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Biosynthetic studies on the deoxyoligosaccharide chain |
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307 | (1) |
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Biosynthetic studies on the single deoxysugar building blocks |
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308 | (5) |
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Oligosacharide antibiotics: Perspective for combinatorial biosynthesis |
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313 | (9) |
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313 | (1) |
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Landomycin and urdamycins |
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313 | (3) |
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Results of investigations |
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316 | (1) |
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Preparation and screening of cosmid libraries |
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316 | (1) |
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316 | (4) |
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320 | (2) |
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Biosynthesis of plant xanthones |
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322 | (7) |
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Xanthone biosynthesis in Centaurium erythraea |
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322 | (2) |
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Xanthone biosynthesis in Hypericum androsaemum |
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324 | (5) |
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Screening of peptide libraries for the identification of mimotopes which crossreact with antibody epitopes |
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329 | (8) |
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329 | (1) |
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330 | (1) |
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Monoclonal antibody anti-Troponin T M7 |
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330 | (1) |
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Monoclonal antibody anti-CK-MB M-6.12.47 |
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330 | (1) |
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Monoclonal antibody anti-CK-MB M-7.4.5 |
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330 | (1) |
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Free peptide model libraries for iterative and positional scanning processes [2,4] |
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330 | (1) |
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Cellulose membrane bound peptide libraries [3] |
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|
331 | (1) |
|
|
|
331 | (1) |
|
|
|
332 | (1) |
|
Biosensor experiments [8] |
|
|
332 | (1) |
|
|
|
332 | (3) |
|
|
|
335 | (2) |
|
Probes for DNA base flipping by DNA methyltransferases |
|
|
337 | (9) |
|
|
|
|
|
|
|
|
|
|
|
DNA methyltransferases and the biological role of DNA methylation |
|
|
337 | (1) |
|
DNA base flipping as observed in X-ray structures of DNA methyltransferases |
|
|
338 | (1) |
|
2-Aminopurine in DNA as fluorescent probe for DNA base flipping |
|
|
338 | (1) |
|
Detection of DNA base flipping |
|
|
339 | (1) |
|
Kinetics of DNA base flipping |
|
|
340 | (2) |
|
Tighter binding of modified DNA to DNA methyltransferases |
|
|
342 | (1) |
|
Binding of duplex ODNs containing a mismatched target base |
|
|
342 | (1) |
|
Binding of duplex ODNs containing an abasic site |
|
|
342 | (1) |
|
Chemical detection of extrahelical bases in DNA---Mtase complexes |
|
|
343 | (1) |
|
Other DNA-modifying enzymes using a DNA base flipping mechanism |
|
|
344 | (2) |
|
Manipulating intracellular signal transduction |
|
|
346 | (12) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
346 | (1) |
|
Confirming known messenger functions |
|
|
347 | (2) |
|
|
|
349 | (4) |
|
|
|
353 | (2) |
|
Conclusions, questions, and perspectives |
|
|
355 | (3) |
|
Physical and Analytical Methods |
|
|
358 | (73) |
|
Adventures with atomic force microscopy |
|
|
358 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Atomic force microscopy (AFM) |
|
|
359 | (1) |
|
|
|
360 | (1) |
|
Chemical force microscopy (CFM) |
|
|
361 | (1) |
|
Chiral discrimination by chemical force microscopy |
|
|
362 | (1) |
|
|
|
363 | (2) |
|
Marine natural products: New ways in the constitutional assignment |
|
|
365 | (14) |
|
|
|
|
|
|
|
|
|
|
|
Constitutional assignment by NMR spectroscopy |
|
|
365 | (3) |
|
ADEQUATE - New NMR experiments for the constitutional assignment |
|
|
368 | (3) |
|
COCON - Translation of NMR correlation data into moelcular constitutions |
|
|
371 | (1) |
|
Constitutional assignment of marine natural products |
|
|
371 | (4) |
|
|
|
375 | (4) |
|
Structural studies of intermolecular interactions by NMR spectroscopy |
|
|
379 | (9) |
|
|
|
|
|
|
|
|
379 | (1) |
|
The bacterial phosphotransferase system |
|
|
380 | (3) |
|
Mapping protein-protein interactions by NMR |
|
|
383 | (2) |
|
|
|
385 | (3) |
|
Tailor-made experimental building blocks for NMR studies of bioorganic compounds |
|
|
388 | (8) |
|
|
|
|
|
|
Computer-aided design of NMR experiments |
|
|
388 | (1) |
|
Tailor-made experiments for the correlation of resonances |
|
|
389 | (1) |
|
Tailor-made experiments for the determination of coupling constants |
|
|
390 | (3) |
|
A new criterion for optimal senistivity |
|
|
393 | (3) |
|
NMR Techniques for the investigation of carbohydrate-protein interactions |
|
|
396 | (13) |
|
|
|
|
|
|
Carbohydrate-protein complexes |
|
|
396 | (1) |
|
|
|
396 | (1) |
|
NMR experiments of carbohydrate-protein complexes - Transferred NOEs |
|
|
397 | (2) |
|
Using transferred NOE experiments to solve the bound conformation of a Streptococcus Group A trisaccharide-antigen [17] |
|
|
399 | (1) |
|
T1p-filtered trNOE experiments |
|
|
400 | (1) |
|
Spin diffusion in trNOE spectra |
|
|
400 | (4) |
|
An investigation of the complex of glucoamylase with a maltose heteroanalog inhibitor [27] |
|
|
404 | (2) |
|
|
|
406 | (3) |
|
Access to structural diversity via chemical screening |
|
|
409 | (9) |
|
|
|
|
|
|
|
|
|
|
|
The chemical screening method |
|
|
409 | (2) |
|
New secondary metabolites from chemical screening |
|
|
411 | (1) |
|
Hydrophilic-chemical screening |
|
|
411 | (1) |
|
Biomolecular-chemical screening |
|
|
412 | (1) |
|
Classification of microbial strain collections |
|
|
413 | (1) |
|
|
|
414 | (2) |
|
|
|
416 | (2) |
|
Carbohydrate - protein interaction studies by various NMR methods and computational calculations |
|
|
418 | (13) |
|
|
|
|
|
|
|
|
418 | (4) |
|
|
|
422 | (1) |
|
|
|
422 | (6) |
|
|
|
428 | (3) |
| Subject Index |
|
431 | |
Other versions by this Author