Cell Engineering

by ;
Format: Hardcover
Pub. Date: 2004-08-01
Publisher(s): Kluwer Academic Pub
List Price: $270.09

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Summary

The series Cell Engineering is the first and only major reference work on the development of cellular systems for the production of recombinant glycoproteins, gene and cell therapies, drug screening and tissue engineering. This volume on "Apoptosis" is intended to review the state-of-the-art with in-depth assessments of this type of programmed cell death. The aim of the volume is to make the recent developments in apoptotic research readily accessible to biologists, biotechnologists and cellular engineers. The implication of apoptosis in the suppression of diseases and prolonging survival of cells in culture is presented to indicate the great potential of apoptotic research for drug production and the development of human therapies. All chapters are written as self-contained treatments of the important topics in apoptosis that are presented on an essential information basis. Topics covered range from understanding the role of signalling and effector molecules, mathematical modelling of cell death, RNAi tools in apoptosis research, to monitoring and imaging of apoptosis. This volume will be an invaluable resource for biotechnologists and researchers in apoptosis, cell biology, cell culture and molecular medicine.

Table of Contents

Understanding the Translation Reulatory Mechanisms to Improve the Efficiency and the Specificity of Protein Production by the Cell Factoryp. 1
Modulation of Gene Expression by Ribozymesp. 38
High Yield Expression of Recombinant Proteins Requiring Proteolytic Maturation: Use of the Endoprotease Furinp. 85
Baculovirus Expression Vectors: Improving Virus-Infected Cell Viability and Recombinant Protein Secretionp. 108
The Regulation of Apoptosis in Animal Cellsp. 122
Inhibition of Apoptosis in Mammalian Cell Culturep. 162
Control of Mammalian Cell Proliferation as an Important Strategy in Cell Culture Technology, Cancer Therapy and Tissue Engineeringp. 186
Development of an IRF-1 Based Proliferation Control Systemp. 220
Factors Involved in the Cell Cyle Arrest of Adult Rat Cardiomyocytesp. 239
Immortalization of Hepatocytes Through Targeted Deregulation of the Cell Cyclep. 255
Subject Indexp. 288
Table of Contents provided by Blackwell. All Rights Reserved.

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