Evaluation of Drug Candidates for Preclinical Development : Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology
by Editor: Chao Han; Editor: Charles B. Davis; Editor: Binghe Wang (Georgia State University, Atlanta )Format: eBook
Pub. Date: 2010-01-01
Publisher(s): Wiley
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Summary
Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug development. This is an enlightening reference for scientists, medicinal chemists, and others working in drug discovery.
Table of Contents
| Preface | |
| ContributorS | |
| Introduction | |
| Pharmacokinetics In Preclinical Drug Development: An Overview | |
| The Role Of Membrane Transporters In Drug Disposition | |
| Cytochrome P450: Structure, Function, And Application In Drug Discovery And Development | |
| The Role Of Drug Metabolism And Metabolite Identification In Drug Discovery | |
| Protein Binding In Drug Discovery And Development | |
| Prediction Of The Pharmacokinetics In Humans | |
| Pharmaceutics Developability Assessment | |
| Safety Assessment In Drug Discovery | |
| Assessment Of Strategies Utilized To Minimize The Potential For Induction Of Acquired Long Qt Syndrome And Torsade De Pointes | |
| Index | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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