Introduction to Proteomics : Principles and Applications

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Format: eBook
Pub. Date: 2010-03-01
Publisher(s): Wiley
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Summary

Proteomics provides an introductory insight on proteomics, discussing the basic principles of the field, how to apply specific technologies and instrumentation, and example applications in human health and diseases. With helpful study questions, this textbook presents an easy to grasp and solid overview and understanding of the principles, guidelines, and especially the complex instrumentation operations in proteomics for new students and research scientists. Written by a leader in proteomics studies, Proteomics offers an expert perspective on the field and the future of proteomics.

Table of Contents

Foreword
Preface
About the AUTHOR
Historical Perspectives
Introduction to Proteomics
Proteome and Proteomics
Genetics of Proteins
Molecular Biology of Genes and Proteins
Protein Chemistry Before Proteomics
References
Further reading
Proteomics-Relation to Genomics, Bioinformatics
Genomics
Bioinformatics and Computational Biology
References
Further reading
Methodology for Separation and Identification of Proteins and Their Interactions
Separation of Proteins Via a Multidimensional Approach
Determination of the Primary Structure of Proteins
Determination of the 3D Structure of a Protein
Determination of the Amount of Proteins
Structural and Functional Proteomics
References
Further reading
Proteomics of Protein Modifications
Phosphorylation and Phosphoproteomics
Glycosylation and Glycoproteomics
Ubiquitination and Ubiquitinomics
Miscellaneous Modifications of Proteins
References
Further reading
Proteomics of Protein-Protein Interactions/Interactomes
Protein-Protein Interactions (PPI) in Vivo
Analysis of Protein Interactions in Vitro
Analysis of Protein Interactions in Silico
Synthetic Genetic Methods to Determine Protein Interactions
Interactomes
Evolution and Conservation of Interactomes
Interactomes and the Complexity of Organisms: It is the Number of Interactomes that Matters in Understanding the Complexity of an Organism and not the Number of Genes
Interaction of Proteins with Small Molecules
References
Further reading
Applications of Proteomics I: Proteomics, Human Disease, and Medicine
Diseasome
Medical Proteomics
Clinical Proteomics
Metaproteomics and Human Health
Proteomics in Biotechnology and Industry of Drug Production
Metaproteomics of Microbial Fermentation
Beef Industry
Bioterrorism and Biodefense
References
Further reading
Proteomics-Future Developments
Technical Scope of Proteomics-Beyond Protein Identification
Scientific Scope of Proteomics-Control of Epigenesis
Medical Scope of Proteomics
Proteomics, Energy Production, and Bioremediation
Proteomics and Biodefense
References
Further reading
Index
Table of Contents provided by Publisher. All Rights Reserved.

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