Name Reactions in Heterocyclic Chemistry

by
Edition: 1st
Format: Hardcover
Pub. Date: 2004-10-11
Publisher(s): Wiley-Interscience
List Price: $293.81

Buy New

Usually Ships in 8 - 10 Business Days.
$279.82

Rent Textbook

Select for Price
There was a problem. Please try again later.

Used Textbook

We're Sorry
Sold Out

eTextbook

We're Sorry
Not Available

How Marketplace Works:

  • This item is offered by an independent seller and not shipped from our warehouse
  • Item details like edition and cover design may differ from our description; see seller's comments before ordering.
  • Sellers much confirm and ship within two business days; otherwise, the order will be cancelled and refunded.
  • Marketplace purchases cannot be returned to eCampus.com. Contact the seller directly for inquiries; if no response within two days, contact customer service.
  • Additional shipping costs apply to Marketplace purchases. Review shipping costs at checkout.

Summary

Covers important name reactions relevant to heterocyclic chemistryThe field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information, it is often a difficult topic to cover for undergraduate and graduate chemistry students, even in simplified form. Yet the chemistry of heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal chemical and pharmaceutical research. Thus there is a great need for high quality, up-to-date, and authoritative books on heterocyclic synthesis helpful to both the professional research chemist as well as the advanced student.Name Reactions in Heterocyclic Chemistry provides a one-stop repository for this important field of organic chemistry. The primary topics include three- and four-membered heterocycles, five-membered heterocycles including indoles, furans, thiophenes, and oxazoles, six-membered heterocycles including quinolines, isoquinolines, and pyrimidines, and other heterocycles.Each name reaction is summarized in seven sections: Description Historical perspective Mechanism Variations and improvements Synthetic utility Experimental References Authored by a team of world-renowned contributors - some of whom have discovered the very reactions they describe - Name Reactions in Heterocyclic Chemistry represents a state-of-the-art resource for students and researchers alike.

Author Biography

JIE JACK LI is a medicinal chemist at Pf izer Global Research and Development in Ann Arbor, Michigan. His research interests include medicinal chemistry, heterocyclic chemistry, transition metal-catalyzed reactions, and radical chemistry. He is author of Name Reactions: A Collection of Detailed Reaction Mechanisms, and coauthor of Palladium in Heterocyclic Chemistry and Contemporary Drug Synthesis, also published by Wiley.

Table of Contents

Foreword x
Preface xi
Acronyms and abbreviations xiv
PART 1 THREE-AND FOUR-MEMBERED HETEROCYCLES
1(68)
Epoxides and Aziridines
1(68)
Corey--Chaykovsky reaction
2(13)
Darzens glycidic ester condensation
15(7)
Hoch--Campbell aziridine synthesis
22(7)
Jacobsen--Katsuki epoxidation
29(15)
Paterno--Buchi reaction
44(6)
Sharpless--Katsuki epoxidation
50(13)
Wenker aziridine synthesis
63(6)
PART 2 FIVE-MEMBERED HETEROCYCLES
69(232)
Pyrroles and Pyrrolidines
69(30)
Barton--Zard reaction
70(9)
Knorr and Paal-Knorr pyrrole syntheses
79(11)
Hofmann--Loffler--Freytag reaction
90(9)
Indoles
99(84)
Bartoli indole synthesis
100(4)
Batcho--Leimgruber indole synthesis
104(6)
Bucherer carbazole synthesis
110(6)
Fischer indole synthesis
116(12)
Gassman indole synthesis
128(4)
Graebe--Ullman carbazole synthesis
132(3)
Hegedus indole synthesis
135(5)
Madelung indole synthesis
140(5)
Nenitzescu indole synthesis
145(9)
Reissert indole synthesis
154(6)
Furans
Feist--Benary furan synthesis
160(8)
Paal--Knorr furan synthesis
168(15)
Thiophenes
183(36)
Fiesselmann thiophene synthesis
184(9)
Gewald aminothiophene synthesis
193(6)
Hinsberg synthesis of thiophene derivatives
199(8)
Paal thiophene synthesis
207(12)
Oxazoles and Isoxazoles
219(42)
Claisen isoxazole synthesis
220(5)
Cornforth rearrangement
225(4)
Erlenmeyer--Plochl azlactone synthesis
229(5)
Fischer oxazole synthesis
234(3)
Meyers oxazoline method
237(12)
Robinson--Gabriel synthesis
249(5)
van Leusen oxazole Synthesis
254(7)
Other Five-Membered Heterocycles
261(40)
Auwers flavone synthesis
262(4)
Bucherer--Bergs reaction
266(9)
Cook--Heilbron 5-amino-thiazole synthesis
275(9)
Hurd--Mori 1,2,3-thiadiazole synthesis
284(108)
Knorr pyrazole synthesis
392
PART 3 SIX-MEMBERED HETEROCYCLES
301(244)
Pyridines
302(73)
Preparation via condensation reactions
303(20)
Hantzsch (dihydro)-pyridine synthesis
304(1)
Description
304(1)
Historical perspective
304(1)
Mechanism
305(2)
Variations
307(1)
Guareschi-Thorpe pyridine synthesis
307(1)
Chichibabin (Tschitschibabin) pyridine synthesis
308(1)
Bohlmann--Rahtz pyridine synthesis
309(2)
Krohnke pyridine synthesis
311(2)
Petrenko--Kritschenko piperidone synthesis
313(1)
Improvements or modifications
314(6)
Experimental
320(1)
Three-component coupling
320(1)
Two-component coupling
320(1)
References
321(2)
Preparation via cycloaddition reactions
323(17)
Boger reaction
323(17)
Preparation via rearrangement reactions
340(15)
Boekelheide reaction
340(10)
Ciamician-Dennstedt rearrangement
350(5)
Zincke reaction
355(20)
Quinolines and Isoquinolines
375(120)
Bischler--Napieralski reaction
376(10)
Camps quinoline synthesis
386(4)
Combes quinoline synthesis
390(8)
Conrad--Limpach reaction
398(9)
Doebner quinoline synthesis
407(4)
Friedlander synthesis
411(5)
Gabriel--Colman rearrangement
416(7)
Gould--Jacobs reaction
423(14)
Knorr quinoline synthesis
437(6)
Meth--Cohn quinoline synthesis
443(8)
Pfitzinger quinoline synthesis
451(6)
Pictet--Gams isoquinoline synthesis
457(8)
Pictet--Hubert reaction
465(4)
Pictet--Spengler isoquinoline synthesis
469(11)
Pomeranz--Fritsch reaction
480(7)
Riehm quinoline synthesis
487(1)
Skraup/Doebner--von Miller reaction
488(7)
Other Six--Membered Heterocycles
495(50)
Algar--Flynn--Oyamada reaction
496(8)
Beirut reaction
504(5)
Biginelli reaction
509(12)
Kostanecki--Robinson reaction
521(15)
Pinner pyrimidine synthesis
536(4)
von Richter cinnoline reaction
540(5)
Subject Index 545

An electronic version of this book is available through VitalSource.

This book is viewable on PC, Mac, iPhone, iPad, iPod Touch, and most smartphones.

By purchasing, you will be able to view this book online, as well as download it, for the chosen number of days.

Digital License

You are licensing a digital product for a set duration. Durations are set forth in the product description, with "Lifetime" typically meaning five (5) years of online access and permanent download to a supported device. All licenses are non-transferable.

More details can be found here.

A downloadable version of this book is available through the eCampus Reader or compatible Adobe readers.

Applications are available on iOS, Android, PC, Mac, and Windows Mobile platforms.

Please view the compatibility matrix prior to purchase.